Rail travellers using London Euston station are facing severe disruption following a fire overnight at a timber yard and offices in north-west London.
There is no service on London Midland, Virgin Trains and Southern between Milton Keynes Central and Euston.
Virgin trains to and from Scotland, north-west England, the West Midlands and north Wales are starting or terminating at Milton Keynes.
London Midland is advising its passengers not to travel on the route.
Network Rail said the blaze had damaged a trackside retaining wall that was "in danger of collapse".
"It will need to be dismantled, made safe and rebuilt," a statement said.
"This a big job expected to take all day. The West Coast main line will remain shut between Euston and Milton Keynes while these repairs are made."
BBC transport correspondent Richard Westcott said the repair work was "not a quick job" as the wall can only be accessed from the railway side and special equipment is needed to access it.
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